陈 坤

发布时间:2018-04-23浏览次数:40



职  称:教授

电子邮箱:ck@zju.edu.cn

 

所属学科


流行病与卫生统计学

 

研究领域


医疗保障

公共卫生

 

重要课题


  1. 长链非编码RNA甲基化与结直肠腺瘤及结直肠癌发生发展的分子流行病学研究,国家自然科学基金,2016-2020。

  2. 老年人健康评估工作与参数规范研制,科技部科技基础性工作专项,2015-2020。

  3. CRC发生和侵袭的前瞻性分子流行病学研究,国家重点基础研究发展计划,2015-2019。

  4. 长链非编码RNA遗传变异与结直肠癌发生发展的分子流行病学研究,国家自然科学基金,2014-2018。

  5. 人口老龄化与长寿风险管理的理论和政策研究,国家社会科学基金,2013-2017。

  6. 真核生物翻译调控通路基因多态性与结直肠癌遗传易感性的人群关联研究, 国家自然科学基金,2011-2014。

  7. 应用TagSNP策略筛选凋亡通路结直肠癌遗传易感性标志的分子流行病学研究,教育部高等学校博士学科点专项科研基金,2010-2013。

  8. Caspase凋亡通路基因多态性与结直肠癌遗传易感性的关联研究,国家自然科学基金,2009-2012。

  9. 重大传染病社区综合防治模式及评价研究,国家科技重大专项,2009-2012。

  10. 国家数字卫生关键技术与区域示范应用研究——全人健康服务流程研究与应用开发,国家科技支撑计划,2008-2011。

 

主要代表作品


  • 主要著作

  1. 临床流行病学(第二版),浙江大学出版社,2018

  2. 流行病学(第8版),人民卫生出版社,2017。

  3. 流行病学,中国协和医科大学出版社,2017。

  4. 流行病学进展,人民卫生出版社,2017。

  5. 现场流行病学,人民卫生出版社,2017。

  6. 癌症进化发育学,第二军医大学出版社,2017。

  7. 公共卫生服务基本技术与方法,人民卫生出版社,2015。

  8. 全人全程健康管理,科学出版社,2012。

  9. 医学科研方法,科学出版社,2011。

  10. 农村公共卫生调查,科学出版社,2009。

  • 主要论文

  1. Gu MJ, Huang QC, Bao CZ, Li YJ, Li XQ, Ye D, Ye ZH, Chen K*, Wang JB. Attributable causes of colorectal cancer in China[J]. BMC CANCER,2018,18.

  2. Li D, Wang JB, Zhang ZY, Shen P, Zheng PW, Jin MJ, Lu HC, Lin HB, Chen K*. Association between short-term exposure to ambient air pollution and daily mortality: a time-series study in Eastern China[J]. Environmental Science & Pollution Research, 2018,25(16):16135-16143.  

  3. Li D, Wang JB, Zhang ZY, Shen P, Zheng PW, Jin MJ, Lu HC, Lin HB, Chen K*. Effects of air pollution on hospital visits for pneumonia in children: a two-year analysis from China[J]. Environmental Science & Pollution Research, 2018,25(10):10049-10057.  

  4. Ye D, Hu Y, Jing F, Li Y, Gu S, Jiang X, Mao Y, Li Q, Jin M, Chen K. A novel SNP in promoter region of RP11-3N2.1 is associated with reduced risk of colorectal cancer. J Hum Genet, 2018, 63(1):47-54.

  5. Jiang X, Cai S, Hu Y, Ye D, Li Q, Chen K, Jin M. Sex disparities in cancer incidence in Jiashan County, 1995-2014. Cancer Epidemiology, 2017, 50:46-52.

  6.  Wu Z, Zhou H, Chen K. The prevalence and drug resistance of strains isolated from cerebrospinal fluid of neurosurgery patients during period of 2011-2015. Chinese Journal of Emergency Medicine, 2017, 26(12):1384-8.

  7. Ye D, Huang QC, Li QL, Jiang XY, Mamat M, Tang ML, Wang JB, Chen K. Comparative Evaluation of Preliminary Screening Methods for Colorectal Cancer in a Mass Program. Digestive Diseases and Sciences, 2017, 62(9):2532-41.

  8. Jin M, Gu S, Ye D, Li Y, Jing F, Li Q, Chen K. Association between genetic variants in the promoter region of a novel antisense long noncoding RNA RP11-392P7.6 and colorectal cancer risk. Environ Mol Mutagen, 2017, 58(6): 434-42.

  9. Ye D, Jiang D, Li Y, Jin M, Chen K. The role of LINE-1 methylation in predicting survival among colorectal cancer patients: a meta-analysis. Int J Clin Oncol,2017, 22 (4):1-9.

  10. Jin M, Ye D, Li Y, Jing F, Jiang X, Mao Y, Li Q, Chen K. Association of a novel genetic variant in RP11-650L12.2 with risk of colorectal cancer in Han Chinese population. Gene, 2017, 624:21-5.

  11. Pei-wen Zheng, Jian-bing Wang, Zhen-yu Zhang, Peng Shen, Peng-fei Chai, Die Li, Ming-juan Jin, Meng-Ling Tang, Huai-chu Lu, Hong-bo Lin, Kun Chen. Air pollution and hospital visits for acute upper and lower respiratory infections among children in Ningbo, China: A time-series analysis. Environmental Science and Pollution Research, 2017, 24(23):1-10.

  12. Li Y, Bao C, Gu S, Ye D, Jing F, Fan C, Jin M, Chen K. Associations between novel genetic variants in long non-coding RNA MALAT1 promoter and risk of colorectal cancer in Chinese. Oncotarget, 2017, 8 (54) :92604-14

  13. Jing F, Jin H, Mao Y, Li Y, Ding Y, Fan C, Chen K. Genome-wide analysis of long non-coding RNA expression and function in colorectal cancer, Tumour Biol, 2017, 39(5):1010428317703650.

  14. Mingjuan Jin, Ding Ye, Yingjun Li, Fangyuan Jing, Xiyi Jiang, Simeng Gu, Yingying Mao, Qilong Li, Kun Chen. Association of a novel genetic variant in RP11-650L12.2 with risk of colorectal cancer in Han Chinese population. Gene, 2017, 624:21–5.

  15. Chengzhen Bao, Pengfei Chai, Hongbo Lin, Zhenyu Zhang, Zhenhua Ye, Mengjia Gu, Huaichu Lu, Peng Shen, Mingjuan Jin, Jianbing Wang & Kun Chen Association of PM2.5 pollution with the pattern of human activity: a case study of a developed city in Eastern China. Journal of the Air & Waste Management Association, 2016, 66 (12): 1202-13.

  16. Jian-Bing Wang, Meng-Jia Gu, Peng Shen, Qiu-Chi Huang, Chen-Zheng Bao, Zhen-HuaYe, You-Qing Wang, Mamat Mayila, DingYe, Shi-Tong Gu, Hong-Bo Lin, Kun Chen. Body Mass Index and Mortality: A 10-Year Prospective Study in China. Scientific Reports, 2016, 6: 31609.

  17. Li, YJ, Gu, MJ, Jing, FY , Cai, SF, Bao, CZ, Wang, JB, Jin, MJ, Chen, K. Association between physical activity and all cancer mortality: Dose-response meta-analysis of cohort studies. International Journal of Cancer, 2016, 138 (4): 818-32.

  18. Chengzhen Bao, Mamat Mayila, Zhenhua Ye, Jianbing Wang, Mingjuan Jin, Wenjiong He, Kun Chen. Forecasting and Analyzing the Disease Burden of Aged Population in China, Based on the 2010 Global Burden of Disease Study. International Journal of Environmental Research and Public Health, 2015, 12(7): 7172-84.

  19. Wang, FJ; Ding, Y; Mao, YY; Jing, FY; Zhang, ZY; Jiang, LF; Guo, JF; Sun, XJ; Jin, MJ; Chen, K. Associations between hsa-miR-603 polymorphism, lifestyle-related factors and colorectal cancer risk. Cancer Biomark, 2014, 14(4): 225-31.

  20. Zhang, ZY; Wang, JB; Jin, MJ; Li, M; Zhou, LT; Jing, FY; Chen, K. Can medical insurance coverage reduce disparities of income in elderly patients requiring long-term care? The case of the People's Republic of China. Clinical interventions in aging, 2014, 9: 771-7.

  21. Yu, Y; Zheng, S; Zhang, S; Jin, W; Liu, H; Jin, M; Chen, Z; Ding, Z; Wang, L ; Chen, K. Polymorphisms of inflammation-related genes and colorectal cancer risk: a population-based case-control study in China. International of Immunogenetics, 2014, 41: 289-97.

  22. Jing, FY; Mao, YY; Guo, J; Zhang, ZY; Li, YJ; Ye, ZH; Ding, Y; Wang, JB; Jin, MJ; Chen, K. The value of Apolipoprotein B/Apolipoprotein A1 ratio for metabolic syndrome diagnosis in a Chinese population: a cross-sectional study. LIPIDS IN HEALTH AND DISEASE, 2014, 13: 81.

  23. Jing, Fangyuan; Mao, Yingying; Zhang, Zhenyu; Li, Yingjun; Cai, Shaofang; Li, Qilong; Ma, Xinyuan; Jin, Mingjuan; Chen, Kun. The association of phosphatase and tensin homolog deleted on chromosome 10 polymorphisms and lifestyle habits with colorectal cancer risk in a Chinese population. Tumor Biol, 2014, 35(9): 9233-40.

  24.  Mao, YY; Li, YJ; Jing, FY; Cai, SF; Zhang, ZY; Li, QL; Ma, XY; Wang, JB; Jin, MJ; Chen, K. Association of a genetic variant in microRNA-146a with risk of colorectal cancer: a population-based case-control study. Tumor Biol, 2014, 35(7): 6961-67.

  25.  Li YJ, Zhang ZY, Mao YY, Jin MJ, Jing FY, Ye ZH, Chen K. A genetic variant in MiR-146a modifies digestive system cancer risk: a meta-analysis. Asian Pac J Cancer Prev, 2014, 15(1):145-50.

  26.  Zhang SC, Jin W, Liu H, Jin MJ, Chen ZX, Ding ZY, Zheng SS, Wang LJ, Yu YX, Chen K.RPSA gene mutants associated with risk of colorectal cancer among the Chinese population. Asian Pac J Cancer Prev, 2013, 14(12):7127-31.

  27. Ying-Ying Mao, Fang-Yuan Jing, Ming-Juan Jin, Ying-Jun Li, Ye Ding, Jing Guo, Fen-Juan Wang, Long-Fang Jiang, Kun Chen. rs12904 Polymorphism in the 3 ' UTR of EFNA1 is Associated with Colorectal Cancer Susceptibility in a Chinese Population, Asian Pacific Journal of Cancer Prevention, 2013, 14 (9), 5037-41.

  28. Ming-Juan Jin, Bing-Bing Chen, Ying-Ying Mao, Yi-Min Zhu, Yun-Xian Yu, Yin-Yin Wu, Ming-Wu Zhang, Shan-Kuan Zhu, Kun Chen. Prevalence of Overweight and Obesity and Their Associations with Socioeconomic Status in a Rural Han Chinese Adult Population. PLoS ONE, 2013, 8(11):e79946

  29. Mei Li, Yang Zhang, Zhenyu Zhang, Ying Zhang, Litao Zhou, Kun Chen. Rural-Urban Differences in the Long-Term Care of the Disabled Elderly in China, PLoS ONE, 2013, 8(11):e79955

  30. Liu H, Jiang X, Zhang MW, Pan YF, Yu YX, Zhang SC, Ma XY, Li QL, Chen K. Association of CASP9, CASP10 Gene Polymorphisms and Tea Drinking with Colorectal Cancer Risk in Han Chinese Population, Journal of Zhejiang University-SCIENCE B, 2013,14(1):47-57.

  31. Wei X, Zou G, Yin J, Walley J, Zhou B, Yu Y, Tian L, Chen K. Characteristics of high risk people with cardiovascular disease in Chinese rural areas: clinical indictors, disease patterns and drug treatment. PLoS One, 2013, 8(1): e54169.

  32. He Liu, Mei Li, Mingjuan Jin, Fangyuan Jing, Hui Wang and Kun Chen. Public awareness of three major infectious diseases in rural Zhejiang province, China: a cross-sectional study. BMC Infectious Diseases, 2013, 13: 192.

  33. Jin MJ, Cai SF, Guo J, Zhu YM, Li M, Yu YX, Zhang SC, Chen K. Alcohol drinking and all cancer mortality: a meta-analysis. Annals of Oncology, 2013, 24 (3): 807-16.

  34. Hui Wang, Kun Chen, Yifeng Pan, Fangyuan Jing, He Liu. Associations and Impact Factors between Living Arrangements and Functional Disability among Older Chinese Adults. PLoS ONE, 2013, 8(1): e53879.

  35. Guo J, Jin MJ, Zhang MW, Chen K. A genetic variant in miR-196a2 increased digestive system cancer risks: A meta-analysis of 15 case-control studies. PLoS ONE, 2012, 7(1):e30585.

  36. Jiang X, Zhou LT, Zhang SC, Chen K. XPC Polymorphism Increases Risk of Digestive System Cancers: Current Evidence from A Meta-Analysis. Chinese J cancer research, 2012, 24(3):181-9.

  37. Li XY, Yu XB, Liang WW, Yu N, Wang L, Ye XJ, Chen K. Meta-Analysis of Association between Particulate Matter and Stroke Attack. CNS neuroscience & Therapeutics. 2012, 510-8.

  38. Yu YX, Zhang MW, Pan YF, Jin MJ, Jiang X, Zhang SC, Wu YY, Ni Q, Li QL, Chen K. PLA2G4A mutants modified protective effect of tea consumption against colorectal cancer. Int J Colorectal Dis, 2012, 27:1005-13.

  39. Yu Y, Pan Y, Jin M, Zhang M, Zhang S, Li Q, Jiang X, Liu H, Guo J, Liu HChen K: Association of genetic variants in tachykinins pathway genes with colorectal cancer risk. International Journal of Colorectal Disease, 2012, 27(11):1429-36.

  40. Yu Y, Liu H, Jin M, Zhang M, Pan Y, Zhang S, Li Q, Chen K. The joint association of REST and NFKB1 polymorphisms on the risk of colorectal cancer. Ann Hum Genet, 2012, 76(4): 269-76.

  41.  Zhang MW, Jin MJ, Yu YX, Zhang SC, Liu B, Jiang X, Pan YF, Li QL, Ma XY, Chen K. Associations of lifestyle-related factors, hsa-miR-149 and hsa-miR-605 gene polymorphisms with gastrointestinal cancer risk. Mol Carcinogen, 2012, 51:E21-31.

  42. Zhang MW, Jin MJ, Yu YX, Zhang SC, Wu YY, Liu H, Liu H, Chen BB, Li QL, Ma XY, Chen K. Associations of miRNA polymorphisms and female physiological characteristics with breast cancer risk in Chinese population. Eur J Cancer Care, 2012, 21:274-80.

  43. Wu YY, Jin MJ, Liu B, Liang X, Yu YX, Li QL, Ma XY, Yao KY, Chen K. The association of XPC polymorphisms and tea drinking with colorectal cancer risk in a Chinese population. Mol Carcinogen, 2011, 50(3): 189-98.

  44. Jin M, Zhang M, Wu Y, et al. P1-110 Prevalence of overweight and obesity among the middle and old-aged in Eastern China, 2010. Journal of Epidemiology and Community Health, 2011, 65(Suppl 1): A97.

  45. Zhou B, Chen K, Wang JF, Wang H, Zhang SS, Zheng WJ. Quality of Life and Related Factors in the Older Rural and Urban Chinese Populations in Zhejiang Province. Journal of Applied Gerontology, 2011, 30(2): 199-225.

  46. Liu B, Zhang YJ, Jin MJ, Qin Ni, Liang X, Ma XY, Yao KY, Li QL, Chen K. Association of selected polymorphisms of CCND1, p21, and caspase8 With colorectal cancer risk. Mol Carcinogen, 2010, 49: 75-84.

  47. Zhou B, Chen K, Yu YX, Wang H, Zhang SS, Zheng WJ. Individualized health intervention: behavior change and quality of life in an older rural Chinese population. Educational Gerontology, 2010, 36(10-11): 919-39.

  48. Zhang YJ, Liu B, Jin MJ, Qin Ni, Liang X, Ma XY, Yao KY, Li QL, Chen K. Genetic polymorphisms of transforming growth factor-beta1 and its receptors and colorectal cancer susceptibility: a population-based case-control study in China. Cancer Lett, 2009, 275: 102-8.

  49. Wang JF, Zhou B, Zheng WJ, Zhang SS, Wu YY, Chen K. Perceived unmet need for hospitalization service among elderly Chinese people in Zhejiang province. J  Public Health, 2009, 31(4): 530-40.

  50. Wang JF, Wu YY, Zhou B, Zhang SS, Zheng WJ, Chen K. Factors associated with non-use of inpatient hospital care service by elderly people in China. Health Social Care Community, 2009, 17(5): 476-84.

  51. Zhang YJ, Jin MJ, Liu B, Ma XY, Yao KY, Li QL, Chen K. Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: A population based case-control study in China. BMC Cancer, 2008, 8: 256.


奖项情况


  1. 国家数字卫生关键技术和区域示范应用研究获2014年浙江省科技进步奖一等奖及2012年浙江省医药卫生科技创新奖一等奖。

  2. 大肠癌环境暴露和代谢酶基因多态性的分子流行病学研究获2006年浙江省科技进步奖二等奖及浙江省医药卫生科技创新奖一等奖。

  3. 我国大肠癌高危人群防治的基础与临床应用研究获2005年国家科技进步奖二等奖。

  4. 国人结直肠癌环境与宿主因素的流行病学研究获2004年浙江省科技进步奖二等奖及浙江省教育厅奖三等奖。

  5. 海岛居民碘营养状况的对比研究获2004年浙江省科技进步奖三等奖。

  6. 小儿脑性瘫痪的流行病学和病因研究获2003年浙江省科技进步奖二等奖及浙江省医药卫生科技创新奖一等奖。

  7. 人群大肠癌癌前病变阻断及筛查方法优化的综合研究2002年教育部科技进步奖一等奖。

  8. 大肠癌现场二十年防治研究-现场干预及筛检方案优化获2000年浙江省科技进步奖三等奖。